Cutaneous Metastatic Rectal Adenocarcinoma in Zosteriform Distribution

Vol. 28, No. 3, 2016 393 Received March 16, 2015, Revised May 4, 2015, Accepted for publication June 1, 2015 Corresponding author: Jae Eun Choi, Department of Dermatology, Anam Hospital, Korea University College of Medicine, 73 Inchon-ro, Seongbukgu, Seoul 02841, Korea. Tel: 82-2-920-5470, Fax: 82-2-928-7540, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Korean Dermatological Association and The Korean Society for Investigative Dermatology histologically showed vascular proliferation with abundant histiocytic infiltration. Progressive ulceration made AITL diagnose more difficult until the lymph node biopsy result was obtained. However, PD-1 staining for the lymph node and the skin was useful in making the diagnosis. Until now, predominant histiocytic infiltrate in cutaneous AITL such as our case has not been described. Only a few AITL cases have been reported with nodular lesion histologically showing presence of histiocytes. Although histiocytes’ role in cutaneous lymphoma has been described in prominent granulomatous reaction, most cases were of mycosis fungoides and rare cases of AITL. CD68 has been known as negative prognostic marker for lymphoma-associated macrophage in follicular lymphoma and classic Hodgkin’s lymphoma. In our opinion, abundant histiocytic infiltration in cutaneous AITL may be associated with the cutaneous nodules and also with the progressive ulcer, and histiocytes might play a more aggressive role in the clinical features of AITL, which will be evaluated in the future. REFERENCES